Sweet 16 Opening Odds For The 2024 NCAA Tournament

Only 16 teams remain in the 2024 NCAA Tournament. I don't know about you but I seesawed the first couple of rounds in the Big Dance. After going 3-1 Thursday, I gave it all back Friday. Then I went 4-1 Saturday and Sunday in NCAA tourney best bets. Entering the Sweet 16, my betting record for March Madness 2024 games is 11-11 and my balance is -1.3 units. 

Despite nearly having a heart attack, I already miss gambling on college hoops and cannot wait for Thursday to arrive. With that in mind, below are the opening moneylines, spreads, and totals for every Sweet 16 game as of midnight Monday, March 25th from DraftKings Sportsbook. 

Opening Odds For the Sweet 16 of the 2024 NCAA Tournament

Thursday, March 28th 

West Region: 6-seed Clemson Tigers vs. 2-seed Arizona Wildcats at 7:09 p.m. ET

• Moneyline: Clemson (+250) | Arizona (-310)
• Spread: Tigers +7.5 (-110) | Wildcats -7.5 (-110)
• Total — 151 — Over (-110) | Under (-110)

East Region: 5-seed San Diego State Aztecs vs. 1-seed UConn Huskies at 7:39 p.m. ET

• Moneyline: San Diego (+370) | Connecticut (-485)
• Spread: Aztecs +10 (-110) | Huskies -10 (-110)
• Total — 135 — Over (-110) | Under (-110)

Connecticut Huskies PG Tristen Newton dribbles the ball past Northwestern Wildcats SG Ryan Langborg in the 2024 NCAA Tournament at the Barclays Center in Brooklyn. (Brad Penner-USA TODAY Sports)

West Region: 4-seed Alabama Crimson Tide vs. 1-seed North Carolina Tar Heels at 9:50 p.m. ET

• Moneyline: Alabama (+154) | North Carolina (-185)
• Spread: Crimson Tide +3.5 (-110) | Tar Heels -3.5 (-110)
• Total — 174 — Over (-110) | Under (-110)

East Region: 3-seed Illinois Fighting Illini vs. 2-seed Iowa State Cyclones at 10:20 p.m. ET

• Moneyline: Illinois (+120) | Iowa State (-142)
• Spread: Fighting Illini +2.5 (-110) | Cyclones -2.5 (-110)
• Total — 146 — Over (-110) | Under (-110)

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Friday, March 29th 

South Region: 11-seed North Carolina State Wolfpack vs. 2-seed Marquette Golden Eagles at 7:09 p.m. ET

• Moneyline: NC State (+235) | Marquette (-290)
• Spread: Wolfpack +6.5 (-110) | Golden Eagles -6.5 (-110)
• Total — 150.5 — Over (-110) | Under (-110)

Midwest Region: 5-seed Gonzaga Bulldogs  vs. 1-seed Purdue Boilermakers at 7:39 p.m. ET

• Moneyline: Gonzaga (+170) | Purdue (-205)
• Spread: Bulldogs +4.5 (-110) | Boilermakers -4.5 (-110)
• Total — 154 — Over (-110) | Under (-110)

Purdue Boilermakers C Zach Edey looks to pass against the Utah State Aggies at Gainbridge FieldHouse in Indiana. (Trevor Ruszkowski-USA TODAY Sports)

South Region: 4-seed Duke Blue Devils vs. 1-seed Houston Cougars at 9:50 p.m. ET

• Moneyline: Duke (+160) | Houston (-192)
• Spread: Blue Devils +4 (-110) | Cougars -4 (-110)
• Total — 133 — Over (-110) | Under (-110)

Midwest Region: 3-seed Creighton Bluejays vs. 2-seed Tennessee Volunteers at 10:20 p.m. ET

• Moneyline: Creighton (+124) | Tennessee (-148)
• Spread: Bluejays +2.5 (-105) | Volunteers -2.5 (-115)
• Total — 144 — Over (-110) | Under (-110)

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