2025 Final Four Opening Betting Odds: Florida Vs. Auburn, Houston Vs. Duke

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CBS Sports' Ian Eagle said there is "all chalk on the riverwalk" in the 2025 NCAA Tournament. For the first time in 17 years, and second after expanding to 64 teams in 1985, all 1-seeds have made the Final Four: Florida Gators, Duke Blue Devils, Houston Cougars, and Auburn Tigers. 

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The 2025 Final Four tips off Saturday, April 5, at the Alamodome in San Antonio, Texas, and ends with the national championship Monday, April 7. Florida faces Auburn in the first Final Four game Saturday at 6:09 p.m. ET, and Houston plays Duke in the second at 8:49 p.m. ET.

2025 Final Four Opening Odds

Courtesy of DraftKings as of 7:25 p.m.  ET Sunday, March 30.

Florida Gators (34-4) vs. Auburn Tigers (32-5)

Moneyline: Florida (-142) | Auburn (+120)

Spread: Gators -2.5 (-110) | Tigers +2.5 (-110)

Total — 164.5 — Over (-110) | Under (-110)

Florida's path to the Final Four 

  • Round of 64: Norfolk State, 95-69
  • Round of 32: UConn, 77-75
  • Sweet 16: Maryland, 87-71
  • Elite Eight: Texas Tech, 84-79
Florida Gators head coach Todd Golden cuts down the nets after beating the Texas Tech Red Raiders in the Elite Eight of the 2025 NCAA Tournament. (Photo Credit: Kyle Terada-Imagn Images)

Florida Gators head coach Todd Golden cuts down the nets after beating the Texas Tech Red Raiders in the Elite Eight of the 2025 NCAA Tournament. (Photo Credit: Kyle Terada-Imagn Images)

Auburn's path to the Final Four 

  • Round of 64: Alabama State, 83-63
  • Round of 32: Creighton, 82-70
  • Sweet 16: Michigan, 78-65
  • Elite Eight: Michigan State, 70-64

Houston Cougars (34-4) vs. Duke Blue Devils (35-3)

Moneyline: Houston (+170) | Duke (-205)

Spread: Cougars +4.5 (-105) | Blue Devils -4.5 (-115)

Total — 136.5 — Over (-110) | Under (-110)

Houston's path to the Final Four 

  • Round of 64: SIU Edwardsville, 78-40
  • Round of 32: Gonzaga, 81-76
  • Sweet 16: Purdue, 62-60
  • Elite Eight: Tennessee, 69-50
The Houston Cougars face the Duke Blue Devils in the Final Four of the 2025 NCAA Tournament at the Alamodome in San Antonio, Texas. (Photo credit: Trevor Ruszkowski-Imagn Images)

The Houston Cougars face the Duke Blue Devils in the Final Four of the 2025 NCAA Tournament at the Alamodome in San Antonio, Texas. (Photo credit: Trevor Ruszkowski-Imagn Images)

Duke's path to the Final Four 

  • Round of 64: Mount St. Mary's, 93-49
  • Round of 32: Baylor, 89-66
  • Sweet 16: Arizona, 100-93
  • Elite Eight: Alabama, 85-69

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